Muti P 1997

Muti P 1997 Link Shown Between Insulin Resistance, Colon And Breast Cancer EDMONTON -- June 12, 1997 -- University of Buffalo epidemiologists are among the first to show that insulin resistance may significantly increase the risk of death from colon cancer, particularly among women ... research showed that women with characteristics associated with insulin resistance had 10 times the risk of dying from colon cancer than women without these characteristics.

Richardson AP et al 2002 Patients with type 2 diabetes (DM) demonstrate inadequate insulin release, elevated gluconeogenesis, and diminished nonoxidative glucose disposal. Similar metabolic changes occur during systemic injury caused by infection, trauma, or cancer(CA) ….. The increase in glucose production may also be part of the injury response, or it may represent a form of insulin resistance that exists in both the DM and (non-DM) CA patients.

Stoll 1999a The incidence of breast cancer in the Western world runs parallel to that of the major components of the insulin resistance syndrome--hyperinsulinaemia, dyslipidaemia, hypertension and atherosclerosis.

Stoll 1999b This review examines possible mechanisms by which the endocrine-metabolic concomitants of hyperinsulinemia may act as late-stage promoters of mammary carcinogenesis. In Western women, evidence of abdominal obesity associated with hyperinsulinemia increases progressively after the age of 40.

Stoll 1998c It is postulated that either insulin resistance and its concomitants promote the development of breast and colorectal cancers.

Gerber et al 1999 Prevention of hyperinsulinemia, insulin resistance and the accompanying visceral obesity appears to be a major public health task for the prevention of cancers.

This page updated July 4 2002