inspulses

INSULIN PULSATILITY

Hollingdal M et al 2002: Six days of prednisolone treatment resulted in a pertubed high-frequency insulin release in the fasting state whereas the ability of glucose to entrain insulin secretion was preserved. This indicates a mechanism of pertubed glucose-insulin feedback mechanism which causes irregular oscillatory insulin release.

Porksen N. 2002 Equal amounts of insulin presented to target organs have improved action when delivered in a pulsatile manner. Data suggest that impaired pulsatile insulin secretion is an early marker for beta-cell dysfunction in Type II diabetes, and the role of early detection of impaired pulsatility to predict diabetes or to examine mechanisms to cause beta-cell dysfunction is mentioned.

Porksen N. 2002 Insulin concentrations oscillate at a periodicity of 5--15 min per oscillation. These oscillations are due to coordinate insulin secretory bursts, from millions of islets. The generation of common secretory bursts requires strong within-islet and within-pancreas coordination to synchronize the secretory activity from the beta-cell population. The overall contribution of this pulsatile mechanism dominates and accounts for the majority of insulin release. …The mechanism by which overall insulin secretion is regulated through the role of impaired pulsatile release in early type 2 diabetes suggests a predictive value of studies on insulin pulsatility in the development of this disease.

Hauffa BP. 2001In all biological systems, the information content of hormonal signals is conveyed by the modalities of pulsatile hormone secretion. Future development of endocrine therapies will depend on our knowledge of hormonal pulsatility.

Westerlund J et al 2001 The effects of metabolic inhibition on insulin release and the cytoplasmic Ca(2+) concentration ([Ca(2+)](i)) were studied in individually perifused pancreatic islets from ob/ob mice.

Juhl CB et al 2001 The high-frequency oscillatory pattern of insulin release is disturbed in type 2 diabetes. Although sulfonylurea drugs are widely used for the treatment of this disease, their effect on insulin release patterns is not well established. ..assessed the impact …of sulfonylurea (gliclazide) ..Insulin pulsatility was assessed by 1-min interval blood sampling for 75 min ..The data suggest a possible relationship between the improvement in short-term glycemic control and the acute improvement of regularity of the in vivo insulin release process.